Tatyana Gurlo, PhD Assistant Professor Director, Islet Function Core (310) 206-5851 tgurlo@mednet.ucla.edu

Tatyana Gurlo has a background in immunology and autoimmune disease of Type-1 diabetes. Tatyana's current work is focused on vaccine strategies to protect beta cells in type-2 diabetes, and on the balance between cell death and cell formation in the diabetic pancreas.

Tatyane Gurlo Publications

1. Liu Z, Gurlo T, and von Grafenstein H. Cell-ELISA using b-galactosidase conjugated antibodies. J. Immunol. Methods 234, 153-167, 2000.
Abstract

2. Ganapathy V, Gurlo T, Jarstadmarken HO, and von Grafenstein H. Regulation of TCR-induced IFN-g release from islet-reactive NOD CD8+ T cells by PGE2 receptor signaling. Int. Immunol. 12, 851-860, 2000.
Abstract

3. Gurlo T, von Grafenstein, H. Antigen-independent cross-talk between macrophages and CD8+ T cells facilitates their cooperation during target destruction. Int. Immunol. 15, (9), 1-9, 2003.
Abstract

4. Butler AE, Jang J, Gurlo T, Soeller WC, Butler PC. Diabetes due to a progressive defect in beta cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. Diabetes. 53, (6), 1509-16, 2004.
Abstract

5. Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC. Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86.
Abstract

6. Meier J, Ritzel RA, Maedler K, Gurlo T, Butler PC. Increased vulnerability of newly forming beta cells to cytokine-induced cell death. Diabetologia. 2006 Jan;49(1):83-9.
Abstract

7. Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Landen R, Glabe CC, Butler PC. Inhibition of hIAPP fibril formation does not prevent beta-cell death: Evidence for distinct actions if oligomers and fibrils of hIAPP. Am J Physiol Endocrinol Metab. 2006 Jul 18; [Epub ahead of print]
Abstract

Selected Publications

1. Gurlo TG, Orlov SN, Aksentsev SL, Okun IM, Konev SV. Inward and outward potassium fluxes (86Rb+) in human and rat erythrocytes: volume change regulation. Biol. Membrany 8, 727-735-1991.

2. Gurlo TG, Aksentsev SL, Okun IM, Konev SV, Pokudin NI, Kubatiev AA, Orlov SN. Involvement of membrane carcass and phospholipid metabolism intermediates in volume regulation of Na+, K+, 2Cl-- and K+, CI-cotransport in rat erythrocytes. Biol. Membrany 8, 870-875, 1991.

3. Orlov SN, Pokudin NI, Gurlo TG, Okun IM, Aksentsev SL, Konev SV. On the mechanism of shrinkage-induced potassium influx in rat and human erythrocytes. Gen. Physiol. Biophys. 10, 359-372, 1991.

4. Orlov SN, Gurlo TG. Volume-sensitive ion transport: mechanisms of intracellular signaling. Tsitologiya 33, 101-110, 1991.

5. Orlov, SN, Kolosova IA, Cragoe EJ, Gurlo TG, Mongin AA, Aksentsev SL, Konev SV. Kinetics and peculiarities of thermal inactivation of volume induced Na+/H+-exchange, Na+, K+, 2Cl--cotransport in rat erythrocytes. Biochim. Biophys. Acta 1151, 186-192, 1993.

6. Aksentsev SL, Gurlo TG, Orlov SN, Mongin AA, Kaler GV, Kolosova IA, Konev SV. Effect of valinomycin on shrinkage-activated Na+/H+-exchange in rat erythrocytes. Biol. Membrany 10, 145-153, 1993.

7. Gurlo TG, Aksentsev SL, Mongin AA, Orlov SN, Kaler GV, Kolosova IA, Konev SV. Effect of the anion transport inhibitor SITS on volume-dependent Na+/H+-excahnge in rat erythrocytes. Biol. Membr. 7(7), 139-144, 1994.

8. Levko AV, Aksentsev SL, Gurlo TG, Konev SV, Orlov SN. Response of the rat erythrocyte glycolytic system to hyperosmotic shrinkage. Biofizika. 40(2):377-82, 1995.

9. Zekzer D, Wong FS, Wen L, Altieri M, Gurlo T, von Grafenstein H, and Sherwin RS. Inhibition of diabetes by an insulin-reactive CD4+ T-cell clone in the nonobese diabetic mouse. Diabetes 46, 1124-32, 1997.

10. Gurlo T, Huang WW, and von Grafenstein H. PGE2 inhibits IL-2 and IL-4-dependent proliferation of CTLL-2 and HT2 cells. Cytokine 10, 265-74, 1998.

11. Gurlo T, Meng WS, Bui HH, Haworth IS, and von Grafenstein H. Experimental evidence for the presence of a water network at the peptide-MHC interface. Immunol. Letters 70, 139-41, 1999.

12. Gurlo T, Kawamura K, and von Grafenstein H. Role of inflammatory infiltrate in activation and effector function of cloned islet reactive nonobese diabetic CD8+ T cells: involvement of a nitric oxide-dependent pathway. J. Immunol. 163, 5770-80, 1999.

13. Liu Z, Gurlo T, and von Grafenstein H. Cell-ELISA using b-galactosidase conjugated antibodies. J. Immunol. Methods 234, 153-167, 2000.

14. Gurlo T, Ganapathy V, Jarstadmarken HO, and von Grafenstein H. Regulation of TCR-induced IFN-g release from islet-reactive NOD CD8+ T cells by PGE2 receptor signaling. Int. Immunol. 12, 851-860, 2000.

15. Gurlo T, von Grafenstein, H. Antigen-independent cross-talk between macrophages and CD8+ T cells facilitates their cooperation during target destruction. Int. Immunol. 15, (9), 1-9, 2003.

16. Butler AE, Jang J, Gurlo T, Soeller WC, Butler PC. Diabetes due to a progressive defect in beta cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. Diabetes. 53, (6), 1509-16, 2004.

17. Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC. Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86.

18. Meier JJ, Ritzel RA, Maedler K, Gurlo T, Butler PC. Increased vulnerability of newly forming beta cells to cytokine-induced cell death. Diabetologia. 2006 Jan;49(1):83-9.

19. Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Landen R, Glabe CC, Butler PC. Inhibition of hIAPP fibril formation does not prevent beta-cell death: Evidence for distinct actions if oligomers and fibrils of hIAPP. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1317-24.

20. GurloT, Lin CY, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC. Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice. Diabetes. 2007 May;56(5):1324-32.

21. Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RE, Butler PC. High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes.
Diabetes. 2007 Aug;56(8):2016-27.

22. Kayed R, Head E, Sarazosa F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener 2007 Sep 26;2(1):18

23. Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC.
Induction of endoplasmic reticulum stress induced beta cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am J Physiol Endocrinol Metab. 2007 Oct 2; [Epub ahead of print]