Aleksey Matveyenko , PhD Assistant Professor (310) 794-7675 amatveyenko@mednet.ucla.edu

Dr. Matveyenko received his Ph.D. from the University of Southern California and his postdoctoral training at the Larry Hillblom Islet research Center at University of California, Los Angeles. Dr. Matveyenko’s primary research goals are to gain insights into molecular and physiological mechanisms underlying metabolic abnormalities in patients with both Type 1 and Type 2 diabetes. Specifically the research is focused on 1) elucidating the mechanisms of diminished pulsatile insulin secretion in Type 2 Diabetes and 2) to ascertain the consequence of impaired pulsatile insulin secretion on liver’s ability to respond to insulin. To accomplish this, the laboratory uses an integrative approach ranging from the cellular and molecular level studies to in-vivo physiology in genetic animal models. Specifically, we seek to investigate how does the pattern of insulin delivery affects the molecular basis of insulin signal transduction pathways in the liver and how does it control expression of genes regulating hepatic insulin action.

Aleksey Matveyenko Publications

Peer Reviewed Publications

1. Sumida, K.D., A.A. Cogger, S.M. Arimoto, and A.V. Matveyenko. Opposing effects of chronic alcohol consumption on hepatic gluconeogenesis for female versus male rats. Alcoholism: Clinical and Experimental Research 29(10): 1899-1905, 2005.

2. Matveyenko, A.V and Donovan, C.M. Metabolic sensors mediate hypoglycemic detection at the portal vein. Diabetes. 55(5): 1276-1282. 2006.

3. Matveyenko, AV and Butler PC. IAPP transgenic rodents as models for type 2 diabetes. ILAR J. 47:225-233, 2006.

4. Matveyenko, AV and Butler PC. Specific beta-cell deficit due to increase in beta-cell apoptosis recapitulates metabolic defects present in type 2 diabetes. Diabetes. Jul;55(7):2106-14, 2006

5. Matveyenko, A.V, Veldhuis J.D and Butler P.C. Mechanism of Impaired Fasting Glucose and Glucose Intolerance induced by ~ 50% pancreatectomy. Diabetes. 55(8):2347-2357, 2006.

6. Sumida, K.D., Cogger, A., Matveyenko, A.V. Alcohol-induced suppression of gluconeogenesis is greater in ethanol fed female rat hepatocytes than males. Alcohol 2007 (1-9).

7. Sumida, K.D., Hill J.M., Matveyenko, A.V. Sex Differences in Glucose Homeostasis After Chronic Alcohol Consumption in Rats. Clinical Medicine & Research 2007 5: 193-202

8. Matveyenko, A.V and Donovan, C.M. Antecedent Portal Vein Hypoglycemia is Essential for the Induction of Full Hypoglycemia Associated Sympathoadrenal Failure. American Journal of Physiology (Endocrinology and Metabolism) 293E1-8, 2007

9. Luan Shu, Nadine S. Sauter, Fabienne T. Schulthess, Matveyenko, A.V. José Oberholzer and Kathrin Maedler. TCF7L2 regulates ?-cell survival and function in human pancreatic islets. Diabetes. 2008 Mar;57(3):645-53

10. Matveyenko, A.V, Veldhuis J.D and Butler P.C Measurement of Pulsatile Insulin Secretion in the Rat, Direct Sampling From the Hepatic Portal Vein. American Journal of Physiology (Endocrinology and Metabolism) in Press 2008.

11. Matveyenko, A.V, Veldhuis J.D and Butler P.C Adaptations in Pulsatile Insulin Secretion, Hepatic Insulin Clearance and Beta-Cell Mass to Age-Related Insulin Resistance in the Rat. American Journal of Physiology (Endocrinology and Metabolism) in Press 2008.

12. Matveyenko, A.V and Butler P.C Relationship Between Beta-cell Mass and Diabetes Onset. Diabetes, Obesity and Metabolism in press 2008.

Published Abstracts

1. Sumida, K.D., A. Matveyenko, A. Cogger, S. Crandall and D. Wellman. Hepatic Gluconeogenic Capacity in Male and Female Rats After Chronic Alcohol Consumption. FASEB J. A91, 2000

2.Matveyenko, A.V and C.M Donovan. Selective Elevation of Portal Vein Pyruvate Concentration Suppresses the Sympathoadrenal Response to Insulin-Induced Hypoglycemia. American Diabetes Association, 2002 (Late Breaking Abstract)

3. Matveyenko, A. V., Fujita, S., Donovan, C.M. Local Portal Vein Hyperlactatemia Suppresses the Sympathoadrenal Response to Hypoglycemia. Diabetes 50 (S2): A73, 2002

4. Matveyenko, A.V., Saberi, M., Donovan, C.M. Suppression of the Sympathetic Response to Hypoglycemia by Ketones is Not Mediated by Portal Vein Glucosensors. Diabetes 52 (S2): 127-OR, 2003

5. Matveyenko, A.V and Donovan, C.M. Antecedent Hypoglycemia Local to the Portal Vein Induces Hypoglycemia Associated Sympathoadrenal Failure. Diabetes 53 (S2): 179-OR, 2004

6. Matveyenko A.V and Butler P.C. Increased Beta-Cell Apoptosis Can Cause Metabolic defects in Diabetes. Diabetes 54(S1): 1531-P, 2005

7. Huang, CJ, Lin CY, Matveyenko AV, Butler AE, Rizza RA, Butler PC. Human Islet Amyloid Polypeptide Induces Apoptosis of Pancreatic Beta-Cell through Endoplasmic Reticulum Stress. Diabetes 55(S1): 1526-P, 2006

8. Matveyenko, A.V, Veldhuis J.D and Butler P.C. Mechanism of Impaired Fasting Glucose and Glucose Intolerance induced by ~ 50% pancreatectomy. Diabetes 55(S1): 155-OR, 2006

9. Matveyenko, A.V, Heather Gerber, Ryan Galasso and Peter C. Butler. Development of Islet pathology Comparable to that in Humans with Type 2 Diabetes in the Human IAPP Transgenic Rat Leads to a Deficit in Glucose mediated Pulsatile Insulin Secretion. Diabetes 56(S1): 1489-P, 2007.

10. Matveyenko AV, Gurlo T, Butler AE and Butler PC. The Mechanisms that Distinguish Successful Islet Adaptation to a High Fat Diet Versus Development of Type 2 Diabetes. Diabetes 57(S1): 1582-P, 2008